Protein Summary
Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. No steroid dehydrogenase activity detected.
- ENST00000381249
- ENSP00000370648
- ENSG00000240857
- PAN2
- SDR7C4
- PAN2
- SDR7C4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
virus perturbation | 0.96 | ||
transcription factor perturbation | 0.8 | ||
kinase perturbation | 0.76 | ||
tissue sample | 0.72 | ||
pathway | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.62 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 84 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.62 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 84 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0