Tchem DUT Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

Protein Summary

Description

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P33316
• A8K650
• B4DPR5
• O14785
• Q16708
• Q16860
• Q6FHN1
• Q6NSA3
• Q96Q81
• dUTPase

Gene Name

• DUT

Ensembl ID

• ENST00000331200
• ENSP00000370376
• ENSG00000128951
• ENST00000455976
• ENSP00000405160

Symbol

• dUTPase

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein) perturbation	1
co-expressed gene	0.96
transcription factor perturbation	0.96
virus perturbation	0.94
kinase perturbation	0.93

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Deoxyuridine 5'-triphosphate Nucleotidohydrolase, Mitochondrial

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Deoxyuridine 5'-triphosphate Nucleotidohydrolase, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 492.45   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 364   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 492.45   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 364   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 126

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0