Tbio WRNIP1 ATPase WRNIP1

Protein Summary

Description

Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Plays also a role in the innate immune defense against viruses. Stabilizes the RIG-I/DDX58 dsRNA interaction and promotes RIG-I/DDX58 'Lys-63'-linked polyubiquitination. In turn, RIG-I/DDX58 transmits the signal through mitochondrial MAVS. Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• Q96S55
• B2RDB0
• Q53EP6
• Q59ET8
• Q5W0E2
• Q5W0E4
• Q8WV26
• Q9H681
• Q9NRJ6

Gene Name

• WRNIP1

Ensembl ID

• ENST00000380764
• ENSP00000370141
• ENSG00000124535
• ENST00000380769
• ENSP00000370146
• ENST00000380771
• ENSP00000370148
• ENST00000380773
• ENSP00000370150
• ENST00000618555
• ENSP00000477551

Symbol

• WHIP
• WHIP
• bA420G6.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein complex	1
ligand (protein) perturbation	0.99
molecular function	0.96
interacting protein	0.93
transcription factor binding site profile	0.87

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Helicase / Dna Helicase / Atpase Wrnip1

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Helicase / Atpase Wrnip1

DTO Classes

Protein / Enzyme / Helicase / Dna Helicase / Atpase Wrnip1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.31   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 215   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.31   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0