Tbio SLC7A1 High affinity cationic amino acid transporter 1

Protein Summary

Description

High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues.

Uniprot Accession IDs

• P30825
• Q5JR50
• CAT-1

Gene Name

• SLC7A1

Ensembl ID

• ENST00000380752
• ENSP00000370128
• ENSG00000139514

Symbol

• ATRC1
• ERR
• REC1L
• ERR
• ATRC1
• CAT-1
• HCAT1
• REC1L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.96
small molecule perturbation	0.92
microRNA	0.9
PubMedID	0.84
transcription factor binding site profile	0.84

Protein Classes

PANTHER Classes

Protein / Transporter / Amino Acid Transporter / High Affinity Cationic Amino Acid Transporter 1

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc3 And Slc7 Families Of Heteromeric Amino Acid Transporters (Hats) / Slc7 Family / High Affinity Cationic Amino Acid Transporter 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1968.45   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 186   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1968.45   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0