PIGA
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A
Protein Summary
Necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis. This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized. A related pseudogene is located on chromosome 12. [provided by RefSeq, Jun 2010]
- ENST00000333590
- ENSP00000369820
- ENSG00000165195
- ENST00000482148
- ENSP00000489528
- ENST00000542278
- ENSP00000442653
- ENST00000634582
- ENSP00000489540
- GPI3
- PNH1
- PIG-A
- MCAHS2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.88 | ||
virus perturbation | 0.76 | ||
metabolite | 0.73 | ||
cellular component | 0.7 | ||
microRNA | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 669.03 (req: < 5)
Gene RIFs: 36 (req: <= 3)
Antibodies: 181 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 669.03 (req: >= 5)
Gene RIFs: 36 (req: > 3)
Antibodies: 181 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0