Protein Summary
Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis. This gene encodes a centrosomal protein that interacts with BRCA2, and is required for centriole duplication and cytokinesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
- ENST00000380262
- ENSP00000369614
- ENSG00000170037
- ENST00000563694
- ENSP00000456335
- ENST00000565740
- ENSP00000454840
- LIP8
- LIP8
- PP1221
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
histone modification site profile | 0.71 | ||
transcription factor binding site profile | 0.58 | ||
cellular component | 0.56 | ||
tissue | 0.56 | ||
tissue sample | 0.5 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 34.51 (req: < 5)
Gene RIFs: 16 (req: <= 3)
Antibodies: 187 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 34.51 (req: >= 5)
Gene RIFs: 16 (req: > 3)
Antibodies: 187 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0