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Tbio
ADPRM
Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase

Protein Summary
Description
Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379774
  • ENSP00000369099
  • ENSG00000170222
  • ENST00000468843
  • ENSP00000431622

Symbol
  • C17orf48
  • MDS006
  • C17orf48
  • NBLA03831
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
kinase perturbation
0.71
transcription factor binding site profile
0.65
small molecule perturbation
0.54
tissue sample
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.45   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.45   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0