You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GCNT2
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase

Protein Summary
Description
Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. Isoform C: Determines the expression of the blood group I antigen in erythrocytes. This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265012
  • ENSP00000265012
  • ENSG00000111846
  • ENST00000316170
  • ENSP00000314844
  • ENST00000379597
  • ENSP00000368917
  • ENST00000495262
  • ENSP00000419411
  • ENST00000642698
  • ENSP00000495911
  • ENSG00000285222
  • ENST00000643503
  • ENSP00000493918
  • ENST00000644083
  • ENSP00000494927

Symbol
  • GCNT5
  • II
  • NACGT1
  • II
  • CCAT
  • IGNT
  • ULG3
  • GCNT5
  • GCNT2C
  • NACGT1
  • NAGCT1
  • CTRCT13
  • bA421M1.1
  • bA360O19.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
small molecule perturbation
0.83
transcription factor
0.82
biological process
0.75
PubMedID
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.36   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.36   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0