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Tbio
CNKSR2
Connector enhancer of kinase suppressor of ras 2

Protein Summary
Description
May function as an adapter protein or regulator of Ras signaling pathways. This gene encodes a multidomain protein that functions as a scaffold protein to mediate the mitogen-activated protein kinase pathways downstream from Ras. This gene product is induced by vitamin D and inhibits apoptosis in certain cancer cells. It may also play a role in ternary complex assembly of synaptic proteins at the postsynaptic membrane and coupling of signal transduction to membrane/cytoskeletal remodeling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379510
  • ENSP00000368824
  • ENSG00000149970
  • ENST00000425654
  • ENSP00000397906
  • ENST00000543067
  • ENSP00000444633
  • ENST00000642359
  • ENSP00000496709

Symbol
  • CNK2
  • KIAA0902
  • KSR2
  • CNK2
  • KSR2
  • MAGUIN
  • MRXSHG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
microRNA
0.88
cell type or tissue
0.68
cellular component
0.6
cell line
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.91   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.91   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0