Tbio SLC30A6 Zinc transporter 6

Protein Summary

Description

Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment. This gene encodes a member of a family of proteins that function as zinc transporters. This protein can regulate subcellular levels of zinc in the Golgi and vesicles. Expression of this gene is altered in the Alzheimer's disease brain plaques. [provided by RefSeq, Aug 2016]

Uniprot Accession IDs

• Q6NXT4
• A5YM45
• B7Z901
• Q8N5C9
• Q96NC3
• ZnT-6

Gene Name

• SLC30A6

Ensembl ID

• ENST00000282587
• ENSP00000282587
• ENSG00000152683
• ENST00000357055
• ENSP00000349563
• ENST00000379343
• ENSP00000368648
• ENST00000435660
• ENSP00000399005

Symbol

• ZNT6
• ZNT6
• MST103
• MSTP103

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.93
kinase perturbation	0.81
transcription factor binding site profile	0.74
microRNA	0.64
disease perturbation	0.62

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc30 Zinc Transporter Family / Zinc Transporter 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.83   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 144   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.83   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0