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Tchem
MMEL1
Membrane metallo-endopeptidase-like 1

Protein Summary
Description
Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond (By similarity). The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mainly in testis with weak expression in the brain, kidney, and heart. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378412
  • ENSP00000367668
  • ENSG00000142606
  • ENST00000502556
  • ENSP00000422492
  • ENST00000504800
  • ENSP00000425477
  • ENST00000611357
  • ENSP00000484606
  • ENSG00000277131
  • ENST00000621908
  • ENSP00000482173
  • ENST00000628503
  • ENSP00000486668

Symbol
  • MELL1
  • MMEL2
  • NEP2
  • NL1
  • NL2
  • SEP
  • NEP2
  • MMEL2
  • NEPII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.88
protein domain
0.73
tissue sample
0.6
cellular component
0.58
phenotype
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.62   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.62   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 44
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0