Tbio RCBTB1 RCC1 and BTB domain-containing protein 1

Protein Summary

Description

May be involved in cell cycle regulation by chromatin remodeling. This gene encodes a protein with an N-terminal RCC1 domain and a C-terminal BTB (broad complex, tramtrack and bric-a-brac) domain. In rat, over-expression of this gene in vascular smooth muscle cells induced cellular hypertrophy. In rat, the C-terminus of RCBTB1 interacts with the angiotensin II receptor-1A. In humans, this gene maps to a region of chromosome 13q that is frequently deleted in B-cell chronic lymphocytic leukemia and other lymphoid malignancies. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8NDN9
• Q8IY29
• Q969U9

Gene Name

• RCBTB1

Ensembl ID

• ENST00000258646
• ENSP00000258646
• ENSG00000136144
• ENST00000378302
• ENSP00000367552

Symbol

• CLLD7
• E4.5
• GLP
• CLLD7
• CLLL7
• RDEOA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.94
histone modification site profile	0.9
cell type or tissue	0.77
protein domain	0.73
transcription factor binding site profile	0.7

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Rcc1 And Btb Domain-containing Protein 1

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Rcc1 And Btb Domain-containing Protein 1

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Rcc1 And Btb Domain-containing Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.3   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 220   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.3   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0