Tbio GRXCR2 Glutaredoxin domain-containing cysteine-rich protein 2

Protein Summary

Description

Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection. This gene encodes a protein containing a glutaredoxin domain, which functions in protein S-glutathionylation. A mutation in this gene was found in a family with autoosomal recessive nonsyndromic sensorineural deafness-101. [provided by RefSeq, Jun 2014]

Uniprot Accession IDs

• A6NFK2

Gene Name

• GRXCR2

Ensembl ID

• ENST00000377976
• ENSP00000367214
• ENSG00000204928

Symbol

• DFNB101

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.71
tissue	0.52
cell line	0.51
protein complex	0.41
biological term	0.33

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.43   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 16   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.43   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 16   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0