Protein Summary
This gene encodes a lens-specific intermediate filament-like protein named filensin. The encoded protein is expressed in lens fiber cells after differentiation has begun. This protein functions as a component of the beaded filament which is a cytoskeletal structure found in lens fiber cells. Mutations in this gene are the cause of autosomal recessive cortical juvenile-onset cataract. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
- ENST00000377868
- ENSP00000367099
- ENSG00000125864
- ENST00000377873
- ENSP00000367104
- ENST00000536626
- ENSP00000442522
- CP94
- CP115
- LIFL-H
- CTRCT33
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cellular component | 0.68 | ||
gene perturbation | 0.65 | ||
small molecule perturbation | 0.62 | ||
trait | 0.61 | ||
cell line | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 128.2 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 232 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 128.2 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 232 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0