Tbio AUP1 Ancient ubiquitous protein 1

Protein Summary

Description

May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. The protein encoded this gene is involved in several pathways including quality control of misfolded proteins in the endoplasmic reticulum and lipid droplet accumulation. Lipid droplets are organelles in the cytoplasm that store neutral lipids such as cholesterol esters and trigylycerides to prevent the overabundance of free cholesterol and fatty acids in cells, but also to act as storage for other metabolic processes, such as membrane biogenesis. Reduced expression of this gene results in reduced lipid droplet clustering, a function that is dependent on ubiquitination of the protein. This protein contains multiple domains including a hydrophobic N-terminal domain, an acetyltranferase domain, a ubiquitin-binding CUE domain, and a UBE2B2-binding domain (G2BR). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Uniprot Accession IDs

• Q9Y679
• C0H5W8
• Q9H866
• Q9UNQ6
• Q9Y685

Gene Name

• AUP1

Ensembl ID

• ENST00000377526
• ENSP00000366748
• ENSG00000115307
• ENST00000425118
• ENSP00000403430

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.9
disease perturbation	0.87
transcription factor binding site profile	0.84
kinase perturbation	0.76
interacting protein	0.73

Protein Classes

PANTHER Classes

Protein / Transferase / Acyltransferase / Ancient Ubiquitous Protein 1

DTO Classes

Protein / Enzyme / Transferase / Acyltransferase / Ancient Ubiquitous Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.12   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 179   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.12   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0