Tbio DDAH2 N(G),N(G)-dimethylarginine dimethylaminohydrolase 2

Protein Summary

Description

Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. This gene encodes a dimethylarginine dimethylaminohydrolase. The encoded enzyme functions in nitric oxide generation by regulating the cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. The protein may be localized to the mitochondria. Alternative splicing resulting in multiple transcript variants. [provided by RefSeq, Dec 2014]

Uniprot Accession IDs

• O95865
• A2BEZ7
• DDAH-2

Gene Name

• DDAH2

Ensembl ID

• ENST00000375787
• ENSP00000364943
• ENSG00000213722
• ENST00000375789
• ENSP00000364945
• ENST00000375792
• ENSP00000364949
• ENST00000383409
• ENSP00000372901
• ENSG00000206395
• ENST00000400062
• ENSP00000382935
• ENST00000400063
• ENSP00000382936
• ENST00000411456
• ENSP00000409396
• ENSG00000226634
• ENST00000413532
• ENSP00000402594
• ENST00000413655
• ENSP00000412800
• ENSG00000233076
• ENST00000414455
• ENSP00000404342
• ENSG00000225635
• ENST00000424790
• ENSP00000391632
• ENST00000426149
• ENSP00000412327
• ENSG00000228128
• ENST00000427126
• ENSP00000395372
• ENST00000430482
• ENSP00000408148
• ENSG00000227317
• ENST00000434464
• ENSP00000391833
• ENST00000437889
• ENSP00000399023
• ENST00000443533
• ENSP00000389552
• ENST00000444699
• ENSP00000404851
• ENST00000447101
• ENSP00000405515
• ENST00000451411
• ENSP00000403154
• ENST00000454138
• ENSP00000399357

Symbol

• DDAH
• G6A
• NG30
• G6a
• DDAH
• NG30
• DDAHII
• HEL-S-277

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
PubMedID	0.92
transcription factor binding site profile	0.76
phenotype	0.69
transcription factor	0.61

Protein Classes

PANTHER Classes

Protein / Hydrolase / N(g),n(g)-dimethylarginine Dimethylaminohydrolase 2

DTO Classes

Protein / Enzyme / Hydrolase / N(g),n(g)-dimethylarginine Dimethylaminohydrolase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 354.04   (req: < 5)

Gene RIFs: 43   (req: <= 3)

Antibodies: 247   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 354.04   (req: >= 5)

Gene RIFs: 43   (req: > 3)

Antibodies: 247   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0