Tchem PSMB9 Proteasome subunit beta type-9

Protein Summary

Description

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. [provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• P28065
• B0V0T1
• Q16523
• Q5JNW4

Gene Name

• PSMB9

Ensembl ID

• ENST00000374859
• ENSP00000363993
• ENSG00000240065
• ENST00000383114
• ENSP00000372595
• ENSG00000240118
• ENST00000383234
• ENSP00000372721
• ENSG00000243594
• ENST00000422729
• ENSP00000407233
• ENSG00000243067
• ENST00000427870
• ENSP00000412027
• ENSG00000242711
• ENST00000434471
• ENSP00000393744
• ENSG00000243958
• ENST00000444284
• ENSP00000396813
• ENSG00000239836
• ENST00000453059
• ENSP00000407810
• ENSG00000240508

Symbol

• LMP2
• PSMB6i
• RING12
• LMP2
• PRAAS3
• PSMB6i
• RING12
• beta1i

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.99
virus perturbation	0.99
biological process	0.98
PubMedID	0.91
transcription factor perturbation	0.88

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 731.04   (req: < 5)

Gene RIFs: 55   (req: <= 3)

Antibodies: 387   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 731.04   (req: >= 5)

Gene RIFs: 55   (req: > 3)

Antibodies: 387   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 70

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1