Tbio TMEM38B Trimeric intracellular cation channel type B

Protein Summary

Description

Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. This gene encodes an intracellular monovalent cation channel that functions in maintenance of intracellular calcium release. Mutations in this gene may be associated with autosomal recessive osteogenesis. [provided by RefSeq, Oct 2012]

Uniprot Accession IDs

• Q9NVV0
• Q5JR63
• Q5SVN5
• Q5SVN6
• Q5VTE2
• Q6IA97
• TRIC-B

Gene Name

• TMEM38B

Ensembl ID

• ENST00000374692
• ENSP00000363824
• ENSG00000095209

Symbol

• C9orf87
• OI14
• TRICB
• TRIC-B
• C9orf87
• D4Ertd89e
• bA219P18.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
histone modification site profile	0.89
kinase perturbation	0.88
cellular component	0.67
transcription factor binding site profile	0.66

Protein Classes

DTO Classes

Protein / Ion Channel / Tmem38 Family / Trimeric Intracellular Cation Channel Type B

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.67   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 91   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.67   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0