Tbio MATN1 Cartilage matrix protein

Protein Summary

Description

Cartilage matrix protein is a major component of the extracellular matrix of non-articular cartilage. It binds to collagen. This gene encodes a member of von Willebrand factor A domain containing protein family. This family of proteins are thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. Mutations of this gene have been associated with variety of inherited chondrodysplasias. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P21941
• B2R7E3
• Q5TBB9

Gene Name

• MATN1

Ensembl ID

• ENST00000373765
• ENSP00000362870
• ENSG00000162510

Symbol

• CMP
• CRTM
• CMP
• CRTM

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.69
tissue sample	0.61
protein domain	0.58
microRNA	0.51
gene perturbation	0.49

Protein Classes

PANTHER Classes

Protein / Receptor / Cartilage Matrix Protein

DTO Classes

Protein / Receptor / Cartilage Matrix Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.84   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 201   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.84   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0