Tbio CHD6 Chromodomain-helicase-DNA-binding protein 6

Protein Summary

Description

DNA-dependent ATPase that plays a role in chromatin remodeling. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. This gene encodes a member of the SNF2/RAD54 helicase protein family. The encoded protein contains two chromodomains, a helicase domain, and an ATPase domain. Several multi-subunit protein complexes remodel chromatin to allow patterns of cell type-specific gene expression, and the encoded protein is thought to be a core member of one or more of these chromatin remodeling complexes. The encoded protein may function as a transcriptional repressor and is involved in the cellular repression of influenza virus replication. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• Q8TD26
• Q5JYQ0
• Q5TGZ9
• Q5TH00
• Q5TH01
• Q8IZR2
• Q8WTY0
• Q9H4H6
• Q9H6D4
• Q9NTT7
• Q9P2L1
• CHD-6

Gene Name

• CHD6

Ensembl ID

• ENST00000373222
• ENSP00000362319
• ENSG00000124177
• ENST00000373233
• ENSP00000362330

Symbol

• CHD5
• KIAA1335
• RIGB
• CHD5
• RIGB
• CHD-6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
molecular function	0.99
transcription factor	0.78
kinase perturbation	0.76
transcription factor binding site profile	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.15   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 42   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.15   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0