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Tbio
PCDH11X
Protocadherin-11 X-linked

Protein Summary
Description
Potential calcium-dependent cell-adhesion protein. This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 7 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene is located in a major X/Y block of homology and its Y homolog, despite divergence leading to coding region changes, is the most closely related cadherin family member. The protein is thought to play a fundamental role in cell-cell recognition essential for the segmental development and function of the central nervous system. Disruption of this gene may be associated with developmental dyslexia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361655
  • ENSP00000355105
  • ENSG00000102290
  • ENST00000373088
  • ENSP00000362180
  • ENST00000373094
  • ENSP00000362186
  • ENST00000373097
  • ENSP00000362189
  • ENST00000406881
  • ENSP00000384758
  • ENST00000504220
  • ENSP00000423762

Symbol
  • KIAA1326
  • PCDH11
  • PCDHX
  • PCDHX
  • PCDH-X
  • PCDH-Y
  • PCDH11
  • PCDH22
  • PCDH11Y
  • PPP1R119
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.75
protein domain
0.73
cell type or tissue
0.65
cellular component
0.63
trait
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.05   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.05   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0