Tbio MEAF6 Chromatin modification-related protein MEAF6

Protein Summary

Description

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. This gene encodes a nuclear protein involved in transcriptional activation. The encoded protein may form a component of several different histone acetyltransferase complexes. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Uniprot Accession IDs

• Q9HAF1
• B1AK64
• Q4F967
• Q7Z311
• Q86WE3
• MYST/Esa1-associated factor 6

Gene Name

• MEAF6

Ensembl ID

• ENST00000296214
• ENSP00000296214
• ENSG00000163875
• ENST00000373073
• ENSP00000362164
• ENST00000373075
• ENSP00000362166
• ENST00000448519
• ENSP00000394966

Symbol

• C1orf149
• CENP-28
• EAF6
• EAF6
• CENP-28
• C1orf149
• NY-SAR-91

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.88
cellular component	0.78
cell type or tissue	0.69
transcription factor binding site profile	0.69
hub protein	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.56   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 117   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.56   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0