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Tclin
ABL1
Tyrosine-protein kinase ABL1

Protein Summary
Description
Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses thro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318560
  • ENSP00000323315
  • ENSG00000097007
  • ENST00000372348
  • ENSP00000361423

Symbol
  • ABL
  • JTK7
  • ABL
  • JTK7
  • p150
  • c-ABL
  • v-abl
  • CHDSKM
  • c-ABL1
  • bcr/abl
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical bioactivity profile
1
hub protein
1
kinase
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5222.68   (req: < 5)
Gene RIFs: 552   (req: <= 3)
Antibodies: 2041   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5222.68   (req: >= 5)
Gene RIFs: 552   (req: > 3)
Antibodies: 2041   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 120
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1169
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 11