Tbio ELOVL5 Elongation of very long chain fatty acids protein 5

Protein Summary

Description

Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. This gene belongs to the ELO family. It is highly expressed in the adrenal gland and testis, and encodes a multi-pass membrane protein that is localized in the endoplasmic reticulum. This protein is involved in the elongation of long-chain polyunsaturated fatty acids. Mutations in this gene have been associated with spinocerebellar ataxia-38 (SCA38). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

Uniprot Accession IDs

• Q9NYP7
• B4DZJ2
• F6SH78
• Q59EL3
• Q5TGH5
• Q6NXE7
• Q7L2S5
• Q8NCG4
• Q9UI22

Gene Name

• ELOVL5

Ensembl ID

• ENST00000304434
• ENSP00000306640
• ENSG00000012660
• ENST00000370913
• ENSP00000359951
• ENST00000370918
• ENSP00000359956

Symbol

• ELOVL2
• HELO1
• SCA38
• dJ483K16.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.96
transcription factor perturbation	0.96
disease perturbation	0.95
transcription factor binding site profile	0.87
small molecule perturbation	0.79

Protein Classes

PANTHER Classes

Protein / Transferase / Acyltransferase / Elongation Of Very Long Chain Fatty Acids Protein 5

DTO Classes

Protein / Enzyme / Transferase / Acyltransferase / Elongation Of Very Long Chain Fatty Acids Protein 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 247.85   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 323   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 247.85   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 323   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0