Tbio EXTL2 Exostosin-like 2

Protein Summary

Description

Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains.

Uniprot Accession IDs

• Q9UBQ6
• B2R795
• D3DT60

Gene Name

• EXTL2

Ensembl ID

• ENST00000370113
• ENSP00000359131
• ENSG00000162694
• ENST00000370114
• ENSP00000359132

Symbol

• EXTR2
• EXTR2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.77
tissue sample	0.66
cellular component	0.65
transcription factor	0.63
histone modification site profile	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.34   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 143   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.34   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0