Protein Summary
Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development (By similarity). This gene encodes a protein kinase similar to a protein kinase which is specific for the SR (serine/arginine-rich domain) family of splicing factors. A highly similar protein has been shown to play a role in muscle development in mice. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
- ENST00000370101
- ENSP00000359119
- ENSG00000184343
- ENST00000370104
- ENSP00000359122
- ENST00000393786
- ENSP00000377376
- MSSK1
- STK23
- MSSK1
- STK23
- MSSK-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 0.93 | ||
molecular function | 0.91 | ||
gene perturbation | 0.58 | ||
protein domain | 0.58 | ||
cell type or tissue | 0.5 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.24 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 150 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.24 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 150 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1