Tbio KIAA1324 UPF0577 protein KIAA1324

Protein Summary

Description

May protect cells from cell death by inducing cytosolic vacuolization and upregulating the autophagy pathway. Expression of this gene is induced by estrogen and the encoded protein has been characterized as a transmembrane protein. The encoded protein has been found in to correlate with survival in certain carcinomas (PMID: 21102415) and may be important for cellular response to stress (PMID: 21072319). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

Uniprot Accession IDs

• Q6UXG2
• Q08AE6
• Q5T5C9
• Q5T5D0
• Q5T5D1
• Q9P2M2

Gene Name

• KIAA1324

Ensembl ID

• ENST00000369939
• ENSP00000358955
• ENSG00000116299
• ENST00000529753
• ENSP00000434595

Symbol

• EIG121
• EIG121

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.94
transcription factor perturbation	0.88
cell type or tissue	0.84
histone modification site profile	0.72
PubMedID	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.86   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 168   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.86   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0