Tchem PHGDH D-3-phosphoglycerate dehydrogenase

Protein Summary

Description

Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• O43175
• B2RD08
• Q5SZU3
• Q9BQ01
• 3-PGDH

Gene Name

• PHGDH

Ensembl ID

• ENST00000641023
• ENSP00000493175
• ENSG00000092621
• ENST00000641597
• ENSP00000493382

Symbol

• PGDH3
• NLS
• PDG
• PGD
• NLS1
• PGAD
• PGDH
• SERA
• 3PGDH
• 3-PGDH
• PHGDHD
• HEL-S-113

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
protein complex	1
transcription factor perturbation	0.96
disease perturbation	0.93
kinase perturbation	0.93

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Dehydrogenase / D-3-phosphoglycerate Dehydrogenase

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / D-3-phosphoglycerate Dehydrogenase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2766.08   (req: < 5)

Gene RIFs: 56   (req: <= 3)

Antibodies: 405   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2766.08   (req: >= 5)

Gene RIFs: 56   (req: > 3)

Antibodies: 405   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 198

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0