Tbio PDE4DIP Myomegalin

Protein Summary

Description

Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity). Isoform 13: Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome (PubMed:25217626, PubMed:27666745, PubMed:28814570, PubMed:29162697). In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression (PubMed:29162697).

Uniprot Accession IDs

• Q5VU43
• A0A0A0MRM0
• A0A0C4DFQ0
• A2RU15
• E9PL24
• O75042
• O75065
• Q2YDC1
• Q5VU42
• Q5VU44
• Q5VU45
• Q5VU46
• Q5VU47
• Q5VU48
• Q5VU49
• Q68DU2
• Q6AZ93
• Q6PK88
• Q86T40
• Q86TB2
• Q8N3W0
• Q8TAY9
• Q9HCP2
• Q9HCP3
• Q9HCP4
• Q9HCP5

Gene Name

• PDE4DIP

Ensembl ID

• ENST00000313431
• ENSP00000316434
• ENSG00000178104
• ENST00000369347
• ENSP00000358353
• ENST00000369349
• ENSP00000358355
• ENST00000369351
• ENSP00000358357
• ENST00000369354
• ENSP00000358360
• ENST00000369356
• ENSP00000358363
• ENST00000529945
• ENSP00000433392
• ENST00000530472
• ENSP00000482121
• ENST00000618462
• ENSP00000479409

Symbol

• CMYA2
• KIAA0454
• KIAA0477
• MMGL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
PubMedID	0.97
disease perturbation	0.95
kinase perturbation	0.88
transcription factor	0.87

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.72   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 109   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.72   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0