Tchem ADAM12 Disintegrin and metalloproteinase domain-containing protein 12

Protein Summary

Description

Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity). This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]

Uniprot Accession IDs

• O43184
• O60470
• Q5JRP0
• Q5JRP1
• Q6P9E3
• Q6UWB0
• ADAM 12

Gene Name

• ADAM12

Ensembl ID

• ENST00000368676
• ENSP00000357665
• ENSG00000148848
• ENST00000368679
• ENSP00000357668

Symbol

• MLTN
• MCMP
• MLTN
• CAR10
• MLTNA
• MCMPMltna
• ADAM12-OT1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.98
protein domain	0.92
transcription factor perturbation	0.88
kinase perturbation	0.84
gene perturbation	0.78

Protein Classes

PANTHER Classes

Protein / ... / Metalloprotease / Disintegrin And Metalloproteinase Domain-containing Protein 12

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Disintegrin And Metalloproteinase Domain-containing Protein 12

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 297.58   (req: < 5)

Gene RIFs: 161   (req: <= 3)

Antibodies: 416   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 297.58   (req: >= 5)

Gene RIFs: 161   (req: > 3)

Antibodies: 416   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0