Tbio TSPYL1 Testis-specific Y-encoded-like protein 1

Protein Summary

Description

The protein encoded by this gene is found in the nucleolus and is similar to that of a family of genes on the Y-chromosome. This gene is intronless. Defects in this gene are a cause of sudden infant death with dysgenesis of the testes syndrome (SIDDT). [provided by RefSeq, Dec 2009]

Uniprot Accession IDs

• Q9H0U9
• O75885
• Q5TFE6
• TSPY-like protein 1

Gene Name

• TSPYL1

Ensembl ID

• ENST00000368608
• ENSP00000357597
• ENSG00000189241

Symbol

• TSPYL
• TSPYL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.79
transcription factor binding site profile	0.78
microRNA	0.71
histone modification site profile	0.59
virus perturbation	0.59

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Phosphatase Modulator / Phosphatase Inhibitor / Testis-specific Y-encoded-like Protein 1

Protein / Chaperone / Testis-specific Y-encoded-like Protein 1

DTO Classes

Protein / Enzyme Modulator / Phosphatase Modulator / Phosphatase Inhibitor / Testis-specific Y-encoded-like Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.73   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 118   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.73   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0