Tbio FCRL3 Fc receptor-like protein 3

Protein Summary

Description

Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells (PubMed:23857366). Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling (PubMed:19843936). Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T-cells (PubMed:20190142, PubMed:19494275). This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• Q96P31
• A0N0M4
• A8MTH7
• D3DVD2
• Q5VXZ8
• Q8N6S2
• Q96LA4
• Q96P27
• Q96P28
• Q96P29
• Q96P30
• FcR-like protein 3

Gene Name

• FCRL3

Ensembl ID

• ENST00000368184
• ENSP00000357167
• ENSG00000160856
• ENST00000368186
• ENSP00000357169
• ENST00000477837
• ENSP00000433430
• ENST00000485028
• ENSP00000434331
• ENST00000492769
• ENSP00000435487

Symbol

• FCRH3
• IFGP3
• IRTA3
• SPAP2
• FCRH3
• IFGP3
• IRTA3
• SPAP2
• CD307c

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
phenotype	0.81
tissue	0.59
protein domain	0.58
disease	0.57
cell line	0.55

Protein Classes

PANTHER Classes

Protein / Cell Adhesion Molecule / Fc Receptor-like Protein 3

DTO Classes

Protein / Cell Adhesion / Fc Receptor-like Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.98   (req: < 5)

Gene RIFs: 80   (req: <= 3)

Antibodies: 145   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.98   (req: >= 5)

Gene RIFs: 80   (req: > 3)

Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0