Tbio SDHC Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

Protein Summary

Description

Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. There are several related pseudogenes for this gene on different chromosomes. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2013]

Uniprot Accession IDs

• Q99643
• O75609
• Q3C259
• Q3C2D8
• Q3C2H4
• Q5VTH3

Gene Name

• SDHC

Ensembl ID

• ENST00000342751
• ENSP00000356952
• ENSG00000143252
• ENST00000367975
• ENSP00000356953
• ENST00000392169
• ENSP00000376009
• ENST00000432287
• ENSP00000390558
• ENST00000513009
• ENSP00000423260

Symbol

• CYB560
• SDH3
• CYBL
• PGL3
• QPS1
• SDH3
• CYB560

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
transcription factor perturbation	0.97
cellular component	0.91
transcription factor binding site profile	0.84
co-expressed gene	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1504.89   (req: < 5)

Gene RIFs: 45   (req: <= 3)

Antibodies: 173   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1504.89   (req: >= 5)

Gene RIFs: 45   (req: > 3)

Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0