Tbio STX11 Syntaxin-11

Protein Summary

Description

SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. This gene encodes a member of the syntaxin family. Syntaxins have been implicated in the targeting and fusion of intracellular transport vesicles. This family member may regulate protein transport among late endosomes and the trans-Golgi network. Mutations in this gene have been associated with familial hemophagocytic lymphohistiocytosis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O75558
• E1P598
• O75378
• O95148
• Q5TCL6

Gene Name

• STX11

Ensembl ID

• ENST00000367568
• ENSP00000356540
• ENSG00000135604

Symbol

• FHL4
• HLH4
• HPLH4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.84
transcription factor binding site profile	0.78
virus perturbation	0.76
protein domain	0.73
tissue sample	0.67

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Snare Protein / Syntaxin-11

DTO Classes

Protein / Transporter / Snare Protein / Syntaxin-11

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.89   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 170   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.89   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0