Tdark KLHDC8A Kelch domain-containing protein 8A

Protein Summary

Description

This gene encodes a kelch domain-containing protein which is upregulated in cancer. Upregulated expression of the encoded protein may provide an alternative pathway for tumors to maintain aggressiveness in the absence of epidermal growth factor receptor dependence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Uniprot Accession IDs

• Q8IYD2
• B3KU70
• Q9NVG5

Gene Name

• KLHDC8A

Ensembl ID

• ENST00000367155
• ENSP00000356123
• ENSG00000162873
• ENST00000367156
• ENSP00000356124
• ENST00000539253
• ENSP00000442229

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.75
PubMedID	0.51
gene perturbation	0.48
cell line	0.44
transcription factor binding site profile	0.43

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.28   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 107   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.28   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0