Tbio AHCTF1 Protein ELYS

Protein Summary

Description

Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis.

Uniprot Accession IDs

• Q8WYP5
• A6NGM0
• A8MSG9
• A8MZ86
• Q7Z4E3
• Q8IZA4
• Q96EH9
• Q9Y4Q6

Gene Name

• AHCTF1

Ensembl ID

• ENST00000326225
• ENSP00000355465
• ENSG00000153207
• ENST00000366508
• ENSP00000355464
• ENST00000648844
• ENSP00000497061

Symbol

• ELYS
• TMBS62
• ELYS
• MST108
• TMBS62
• MSTP108

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.91
histone modification site profile	0.88
ligand (protein) perturbation	0.83
disease perturbation	0.79
transcription factor binding site profile	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.32   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 100   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.32   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0