Tbio SMG5 Protein SMG5

Protein Summary

Description

Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity. SMG5 is involved in nonsense-mediated mRNA decay (Ohnishi et al., 2003 [PubMed 14636577]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9UPR3
• D3DVB7
• Q5QJE7
• Q659C7
• Q8IXC0
• Q8IY09
• Q96IJ7

Gene Name

• SMG5

Ensembl ID

• ENST00000361813
• ENSP00000355261
• ENSG00000198952

Symbol

• EST1B
• KIAA1089
• EST1B
• SMG-5
• LPTSRP1
• LPTS-RP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.88
disease perturbation	0.87
transcription factor binding site profile	0.85
histone modification site profile	0.76
tissue	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.85   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 105   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.85   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0