PPEF1
Serine/threonine-protein phosphatase with EF-hands 1
Protein Summary
May have a role in the recovery or adaptation response of photoreceptors. May have a role in development. This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein has been suggested to play a role in specific sensory neuron function and/or development. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced transcript variants, each encoding a distinct isoform, have been described. [provided by RefSeq, Jul 2008]
- ENST00000349874
- ENSP00000341892
- ENSG00000086717
- ENST00000361511
- ENSP00000354871
- PPEF
- PPP7C
- PP7
- PPEF
- PPP7C
- PPP7CA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.99 | ||
molecular function | 0.6 | ||
tissue sample | 0.57 | ||
transcription factor | 0.55 | ||
cell line | 0.53 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 285.57 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 155 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 285.57 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 155 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0