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Tchem
OPA1
Dynamin-like 120 kDa protein, mitochondrial

Protein Summary
Description
Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission (PubMed:16778770, PubMed:17709429, PubMed:20185555, PubMed:24616225, PubMed:28746876). Coexpression of isoform 1 with shorter alternative products is required for optimal activity in promoting mitochondrial fusion (PubMed:17709429). Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation (PubMed:20185555). The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (PubMed:20185555). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space (By similarity). Plays a role in mit ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361150
  • ENSP00000354781
  • ENSG00000198836
  • ENST00000361510
  • ENSP00000355324
  • ENST00000361828
  • ENSP00000354429
  • ENST00000361908
  • ENSP00000354681
  • ENST00000392437
  • ENSP00000376232
  • ENST00000392438
  • ENSP00000376233
  • ENST00000646793
  • ENSP00000494512

Symbol
  • KIAA0567
  • NPG
  • NTG
  • MGM1
  • BERHS
  • largeG
  • MTDPS14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.96
molecular function
0.95
biological term
0.9
virus perturbation
0.9
disease perturbation
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 639.05   (req: < 5)
Gene RIFs: 237   (req: <= 3)
Antibodies: 270   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 639.05   (req: >= 5)
Gene RIFs: 237   (req: > 3)
Antibodies: 270   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0