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Tbio
PRKAR1B
cAMP-dependent protein kinase type I-beta regulatory subunit

Protein Summary
Description
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. The protein encoded by this gene is a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA), which is involved in the signaling pathway of the second messenger cAMP. Two regulatory and two catalytic subunits form the PKA holoenzyme, disbands after cAMP binding. The holoenzyme is involved in many cellular events, including ion transport, metabolism, and transcription. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360274
  • ENSP00000353415
  • ENSG00000188191
  • ENST00000403562
  • ENSP00000385349
  • ENST00000406797
  • ENSP00000385749
  • ENST00000537384
  • ENSP00000440449
  • ENST00000544935
  • ENSP00000444487

Symbol
  • PRKAR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
molecular function
0.96
protein domain
0.92
PubMedID
0.77
pathway
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.31   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 323   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.31   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 323   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0