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Tbio
MYO1C
Unconventional myosin-Ic

Protein Summary
Description
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes. Isoform 3 is involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation (By similarity). This ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359786
  • ENSP00000352834
  • ENSG00000197879
  • ENST00000361007
  • ENSP00000354283
  • ENST00000438665
  • ENSP00000412197
  • ENST00000570984
  • ENSP00000459271
  • ENST00000575158
  • ENSP00000459174
  • ENST00000646049
  • ENSP00000493973
  • ENST00000648446
  • ENSP00000496799
  • ENST00000648651
  • ENSP00000496954

Symbol
  • NMI
  • MMIb
  • myr2
  • MMI-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
molecular function
0.99
transcription factor perturbation
0.97
transcription factor
0.91
biological process
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.33   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.33   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0