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Tbio
ELF3
ETS-related transcription factor Elf-3

Protein Summary
Description
Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359651
  • ENSP00000352673
  • ENSG00000163435
  • ENST00000367283
  • ENSP00000356252
  • ENST00000367284
  • ENSP00000356253

Symbol
  • ERT
  • ESX
  • JEN
  • ERT
  • ESX
  • EPR-1
  • ESE-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
molecular function
0.88
PubMedID
0.86
transcription factor binding site profile
0.83
biological process
0.75


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 433.76   (req: < 5)
Gene RIFs: 74   (req: <= 3)
Antibodies: 378   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 433.76   (req: >= 5)
Gene RIFs: 74   (req: > 3)
Antibodies: 378   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0