Tbio PLGLB1 Plasminogen-like protein B

Protein Summary

Description

May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction.

Uniprot Accession IDs

• Q02325
• Q580R1

Gene Name

• PLGLB1

Ensembl ID

• ENST00000355705
• ENSP00000347933
• ENSG00000183281
• ENST00000359481
• ENSP00000352458
• ENSG00000125551
• ENST00000409310
• ENSP00000386505
• ENST00000409801
• ENSP00000386975
• ENST00000410086
• ENSP00000386317

Symbol

• PLGL
• PRGB
• PRGA
• PLGLA
• PLGP1
• PLGP2
• PLGLA1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.96
cell line	0.81
cell type or tissue	0.81
tissue sample	0.57
virus perturbation	0.41

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.49   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 18   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.49   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 18   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0