Tbio RGR RPE-retinal G protein-coupled receptor

Protein Summary

Description

Receptor for all-trans- and 11-cis-retinal. Binds preferentially to the former and may catalyze the isomerization of the chromophore by a retinochrome-like mechanism. This gene encodes a putative retinal G-protein coupled receptor. The gene is a member of the opsin subfamily of the 7 transmembrane, G-protein coupled receptor 1 family. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P47804
• A6NKK7
• Q96FC5

Gene Name

• RGR

Ensembl ID

• ENST00000358110
• ENSP00000350823
• ENSG00000148604
• ENST00000359452
• ENSP00000352427

Symbol

• RP44

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.88
protein domain	0.73
molecular function	0.53
transcription factor	0.5
cell type or tissue	0.45

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Rpe-retinal G Protein-coupled Receptor

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Rpe-retinal G Protein-coupled Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.22   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 202   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.22   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0