GTPBP3
tRNA modification GTPase GTPBP3, mitochondrial
Protein Summary
GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. This locus encodes a GTP-binding protein. The encoded protein is localized to the mitochondria and may play a role in mitochondrial tRNA modification. Polymorphisms at this locus may be associated with severity of aminoglycoside-induced deafness, a disease associated with a mutation in the 12S rRNA. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2010]
- ENST00000324894
- ENSP00000313818
- ENSG00000130299
- ENST00000358792
- ENSP00000351644
- ENST00000361619
- ENSP00000354598
- ENST00000600625
- ENSP00000473150
- MTGP1
- MSS1
- MTGP1
- THDF1
- GTPBG3
- COXPD23
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.97 | ||
molecular function | 0.91 | ||
transcription factor binding site profile | 0.81 | ||
transcription factor | 0.68 | ||
virus perturbation | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.75 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 101 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.75 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 101 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0