AKAP4
A-kinase anchor protein 4
Protein Summary
Major structural component of sperm fibrous sheath. Plays a role in sperm motility. The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is localized to the sperm flagellum and may be involved in the regulation of sperm motility. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- ENST00000358526
- ENSP00000351327
- ENSG00000147081
- ENST00000376064
- ENSP00000365232
- AKAP82
- HI
- p82
- CT99
- FSC1
- PRKA4
- AKAP-4
- AKAP82
- AKAP 82
- hAKAP82
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cellular component | 0.82 | ||
cell type or tissue | 0.67 | ||
kinase perturbation | 0.6 | ||
gene perturbation | 0.59 | ||
tissue sample | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 157.82 (req: < 5)
Gene RIFs: 21 (req: <= 3)
Antibodies: 132 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 157.82 (req: >= 5)
Gene RIFs: 21 (req: > 3)
Antibodies: 132 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0