Tbio CEACAM3 Carcinoembryonic antigen-related cell adhesion molecule 3

Protein Summary

Description

Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis. This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013]

Uniprot Accession IDs

• P40198
• G5E978
• Q3KPH9

Gene Name

• CEACAM3

Ensembl ID

• ENST00000344550
• ENSP00000341725
• ENSG00000170956
• ENST00000357396
• ENSP00000349971
• ENST00000415495
• ENSP00000411641
• ENST00000630848
• ENSP00000485920

Symbol

• CD66D
• CGM1
• CEA
• CGM1
• W264
• W282
• CD66D

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.73
cell line	0.57
gene perturbation	0.53
cellular component	0.47
tissue sample	0.47

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.82   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 302   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.82   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 302   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0