Tchem CCRL2 C-C chemokine receptor-like 2

Protein Summary

Description

Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses. This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O00421
• B4DKQ8
• O75307
• Q4VBB0
• Q6IPX0
• Q7KYQ9
• Q96KP5
• Q9UPG0

Gene Name

• CCRL2

Ensembl ID

• ENST00000357392
• ENSP00000349967
• ENSG00000121797
• ENST00000399036
• ENSP00000381994
• ENST00000400880
• ENSP00000383677
• ENST00000400882
• ENSP00000383678

Symbol

• CCR11
• CCR6
• CKRX
• CRAM
• HCR
• HCR
• CKRX
• CRAM
• ACKR5
• CRAM-A
• CRAM-B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.7
transcription factor	0.69
molecular function	0.67
PubMedID	0.62
gene perturbation	0.6

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Chemokine Receptor / C-c Chemokine Receptor / C-c Chemokine Receptor-like 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 388.67   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 405   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 388.67   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 405   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 93

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0