Tbio RAET1E Retinoic acid early transcript 1E

Protein Summary

Description

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q8TD07
• A6YF59
• Q5VYB7
• Q5VYB8
• Q8TEZ2
• Q96L41

Gene Name

• RAET1E

Ensembl ID

• ENST00000357183
• ENSP00000349709
• ENSG00000164520
• ENST00000367363
• ENSP00000356332
• ENST00000529948
• ENSP00000432366
• ENST00000532335
• ENSP00000437067

Symbol

• LETAL
• N2DL4
• ULBP4
• RL-4
• LETAL
• ULBP4
• N2DL-4
• NKG2DL4
• RAET1E2
• bA350J20.7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.76
tissue	0.46
cell line	0.44
disease	0.44
cellular component	0.41

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.24   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 318   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.24   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 318   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0