Tbio XPNPEP3 Xaa-Pro aminopeptidase 3

Protein Summary

Description

Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala (PubMed:25609706, PubMed:28476889). Also shows low activity towards peptides with Ala or Ser at the P1 position (PubMed:28476889). Isoform 1: Promotes TNFRSF1B-mediated phosphorylation of MAPK8/JNK1 and MAPK9/JNK2, suggesting a function as an adapter protein for TNFRSF1B; the effect is independent of XPNPEP3 peptidase activity. May inhibit apoptotic cell death induced via TNF-TNFRSF1B signaling. The protein encoded by this gene belongs to the family of X-pro-aminopeptidases that utilize a metal cofactor, and remove the N-terminal amino acid from peptides with a proline residue in the penultimate position. This protein has been shown to localize to the mitochondria of renal cells, and have a role in ciliary function. Mutations in this gene are associated with nephronophthisis-like nephropathy-1. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene, however, expression of some of these isoforms in vivo is not known.[provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• Q9NQH7
• B2R9G1
• B7Z790
• B7Z7B2
• Q6I9V9
• Q8NDA6
• Q9BV27
• Q9BVH0
• X-Pro aminopeptidase 3

Gene Name

• XPNPEP3

Ensembl ID

• ENST00000357137
• ENSP00000349658
• ENSG00000196236

Symbol

• APP3
• ICP55
• NPHPL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.76
histone modification site profile	0.71
microRNA	0.71
small molecule perturbation	0.71
tissue sample	0.67

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Xaa-pro Aminopeptidase 3

Protein / Nucleic Acid Binding / Xaa-pro Aminopeptidase 3

Protein / Hydrolase / Protease / Metalloprotease / Xaa-pro Aminopeptidase 3

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Probable Xaa-pro Aminopeptidase 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.56   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 133   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.56   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0